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Papers of the Week

2020 Apr 13

Cell Mol Gastroenterol Hepatol

Perturbed mitochondrial dynamics is a novel feature of colitis that can be targeted to lessen disease.


Mancini NL, Goudie L, Xu W, Sabouny R, Rajeev S, Wang A, Esquerre N, Al Rajabi A, Jayme TS, van Tilburg Bernandes E, Nasser Y, Ferraz JGP, Shutt T, Shearer J, McKay DM
Cell Mol Gastroenterol Hepatol. 2020 Apr 13.
PMID: 32298841.


Mitochondria exist in a constantly remodelling network, and excessive fragmentation can be pathophysiological. Mitochondrial dysfunction can accompany enteric inflammation, but any contribution of altered mitochondrial dynamics (i.e. fission/fusion) to gut inflammation is unknown. We hypothesised that perturbed mitochondrial dynamics would contribute to colitis.