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Papers of the Week

Papers: 18 Apr 2020 - 24 Apr 2020

Human Studies


2020 Apr 16

J Headache Pain



Short-latency afferent inhibition and somato-sensory evoked potentials during the migraine cycle: surrogate markers of a cycling cholinergic thalamo-cortical drive?


Coppola G, Di Lenola D, Abagnale C, Ferrandes F, Sebastianelli G, Casillo F, Di Lorenzo C, Serrao M, Evangelista M, Schoenen J, Pierelli F
J Headache Pain. 2020 Apr 16; 21(1):34.
PMID: 32299338.


Short-latency afferent inhibition (SAI) consists of motor cortex inhibition induced by sensory afferents and depends on the excitatory effect of cholinergic thalamocortical projections on inhibitory GABAergic cortical networks. Given the electrophysiological evidence for thalamo-cortical dysrhythmia in migraine, we studied SAI in migraineurs during and between attacks and searched for correlations with somatosensory habituation, thalamocortical activation, and clinical features.