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Papers of the Week

2020 Apr 10

Pain Med

Effects of Food on Bioavailability of Analgesics; Resulting Dosage and Administration Recommendations.


Naraharisetti S B, Srour S, Xu Y, Lee DJ, Hertz SH, Sahajwalla C
Pain Med. 2020 Apr 10.
PMID: 32274507.


To evaluate currently approved analgesics, that is, opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), anticonvulsants, and serotonin and norepinephrine reuptake inhibitors (SNRIs) used as analgesics, for 1) differences in pharmacokinetic parameters under fed vs fasting conditions and 2) factors involved in dosage recommendations in relation to food.