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Papers of the Week

2020 Apr 01

Korean J Pain



Increased calcium-mediated cerebral processes after peripheral injury: possible role of the brain in complex regional pain syndrome.


Nahm F S, Lee J-S, Lee P-B, Choi E J, Han W K, Nahm S-S
Korean J Pain. 2020 Apr 01; 33(2):131-137.
PMID: 32235013.


Among various diseases that accompany pain, complex regional pain syndrome (CRPS) is one of the most frustrating for patients and physicians. Recently, many studies have shown functional and anatomical abnormalities in the brains of patients with CRPS. The calcium-related signaling pathway is important in various physiologic processes calmodulin (CaM) and calcium-calmodulin kinase 2 (CaMK2). To investigate the cerebral mechanism of CRPS, we measured changes in CaM and CaMK2 expression in the cerebrum in CRPS animal models.