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Papers of the Week

2020 Apr 02

J Neuroinflammation



Normalization of magnesium deficiency attenuated mechanical allodynia, depressive-like behaviors, and memory deficits associated with cyclophosphamide-induced cystitis by inhibiting TNF-α/NF-κB signaling in female rats.


Chen J-L, Zhou X, Liu B-L, Wei X-H, Ding H-L, Lin Z-J, Zhan H-L, Yang F, Li W-B, Xie J-C, Su M-Z, Liu X-G, Zhou X-F
J Neuroinflammation. 2020 Apr 02; 17(1):99.
PMID: 32241292.


Bladder-related pain symptoms in patients with bladder pain syndrome/interstitial cystitis (BPS/IC) are often accompanied by depression and memory deficits. Magnesium deficiency contributes to neuroinflammation and is associated with pain, depression, and memory deficits. Neuroinflammation is involved in the mechanical allodynia of cyclophosphamide (CYP)-induced cystitis. Magnesium-L-Threonate (L-TAMS) supplementation can attenuate neuroinflammation. This study aimed to determine whether and how L-TAMS influences mechanical allodynia and accompanying depressive symptoms and memory deficits in CYP-induced cystitis.