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Papers: 28 Mar 2020 - 3 Apr 2020

2020 Mar 31

Protein Sci

High-resolution structures of TRPV channels: unveiling a functionally diverse group of ion channels.


van Goor MK, de Jager L, Cheng Y, van der Wijst J
Protein Sci. 2020 Mar 31.
PMID: 32232875.


Transient receptor potential vanilloid (TRPV) channels are part of the superfamily of TRP ion channels and play important roles in widespread physiological processes including both neuronal and non-neuronal pathways. Various diseases such as skeletal abnormalities, chronic pain, and cancer are associated with dysfunction of a TRPV channel. In order to obtain full understanding of disease pathogenesis and create opportunities for therapeutic intervention, it is essential to unravel how these channels function at a molecular level. In the past decade, incredible progress has been made in biochemical sample preparation of large membrane proteins and structural biology techniques, including cryo-electron microscopy. This has resulted in high resolution structures of all TRPV channels, which has provided novel insights into the molecular mechanisms of channel gating and regulation that will be summarized in this review. This article is protected by copyright. All rights reserved.