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Papers of the Week

Papers: 28 Mar 2020 - 3 Apr 2020

2020 Mar 27

Br Med Bull

Understanding the genetic basis of congenital insensitivity to pain.


Drissi I, Woods W A, Woods C G
Br Med Bull. 2020 Mar 27.
PMID: 32219415.


Congenital insensitivity to pain (CIP) is caused by extremely rare Mendelian genetic disorders. CIP individuals demonstrate the unexpectedly severe consequences of painlessness. Although only a small number of causative conditions and genes are known, most have led to profound insights into human nociception. CIP gene discovery is catalyzing the manufacture of completely new classes of analgesics, and these are needed as alternatives to synthetic highly potent opioids.