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Papers of the Week

Papers: 28 Mar 2020 - 3 Apr 2020

Human Studies


J Pain Res


Toll-Like Receptor Responsiveness of Peripheral Blood Mononuclear Cells in Young Women with Dysmenorrhea.


Evans SF, Kwok YH, Solterbeck A, Liu J, Hutchinson MR, Hull LM, Rolan PE
J Pain Res. 2020; 13:503-516.
PMID: 32210607.


Dysmenorrhea is a common disorder that substantially disrupts the lives of young women. To determine whether there is evidence of activation of the innate immune system in dysmenorrhea and whether the degree of activation may be used as a biomarker for pain, we compared the responsiveness of peripheral blood mononuclear cells (PBMCs) to toll-like receptor (TLR) 2 or 4 stimulation. We also investigated whether this effect is modulated by the use of the oral contraceptive pill (OC).