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Papers: 14 Mar 2020 - 20 Mar 2020

Human Studies

2020 Mar 16

BMJ Open



Phase II double-blind randomised controlled trial of exogenous administration of melatonin in chronic pain (DREAM-CP): a study protocol.


Adam R, Kanakarajan S, Onyeakazi U, Columb M, Galley H
BMJ Open. 2020 Mar 16; 10(3):e034443.
PMID: 32184313.


Chronic pain is prevalent, and approximately half of patients with chronic pain experience sleep disturbance. Exogenous melatonin is licensed to treat primary insomnia and there is some evidence for analgesic effects of melatonin.The aim of this study is to investigate the effects of oral melatonin (as Circadin) 2 mg at night in adults with severe non-malignant pain of at least 3 months' duration.