Prosthetic repair of inguinal hernias is one of the most performed surgical procedures. Nevertheless, high rates of complications affect the surgical treatment. Implant fixation, poor-quality tissue ingrowth and mesh shrinkage seem to be involved in postoperative complications, discomfort and chronic pain following inguinal hernia repair. To address these issues a multilamellar shaped 3D dynamic responsive prosthesis has been developed. This new implant, positioned fixation-free to obliterate the hernia opening, thanks its inherent dynamic compliance during inguinal movements, has demonstrated to induce an enhanced biological response. The ingrowth of newly formed muscle fibers, arteries and veins in a surrounding of viable connective tissue could be evidenced into the implant fabric. This appears to be quite different from the fibrotic plaque, typical biologic response of conventional meshes. In addition to myocytes and vessels, newly ingrown nerves have also been detected in the prosthetic structure.