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Papers of the Week

Papers: 7 Mar 2020 - 13 Mar 2020

Animal Studies, Pharmacology/Drug Development

2020 Mar 10

Br J Pharmacol

Improved efficacy, tolerance, safety and abuse liability profile of the combination CR4056-morphine over morphine alone in rodent models.


Sala E, Ferrari F, Lanza M, Milia C, Sabatini C, Bonazzi A, Comi E, Borsi Franchini M, Caselli G, Rovati L C
Br J Pharmacol. 2020 Mar 10.
PMID: 32154915.


Prolonged use of opioids causes analgesic tolerance and adverse effects including constipation and dependence. Evidence exists that molecules targeting imidazoline-2 receptors (I2Rs) potentiate opioid analgesia in rodents. We investigated whether combination with the I2R ligand CR4056 could improve efficacy and safety of morphine, and explored the mechanisms of CR4056-opioid interaction.