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Papers of the Week

Papers: 22 Feb 2020 - 28 Feb 2020

Animal Studies

2020 Feb 26

Eur J Pain

Differential gene expression changes in the dorsal root versus trigeminal ganglia following peripheral nerve injury in rats.


Korczeniewska OA, Katzmann Rider G, Gajra S, Narra V, Ramavajla V, Chang YJ, Tao YX, Soteropoulos P, Husain S, Khan J, Eliav E, Benoliel R
Eur J Pain. 2020 Feb 26.
PMID: 32100907.


The dorsal root (DRG) and trigeminal (TG) ganglia contain cell bodies of sensory neurons of spinal and trigeminal systems, respectively. They are homologs of each other; however, differences in how the two systems respond to injury exist. Trigeminal nerve injuries rarely result in chronic neuropathic pain (NP). To date, no genes involved in the differential response to nerve injury between the two systems have been identified. We examined transcriptional changes involved in the development of trigeminal and spinal NP.