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Papers of the Week

Papers: 22 Feb 2020 - 28 Feb 2020

Animal Studies

2020 Feb 19


Synaptic Dynamics of the Feed-forward Inhibitory Circuitry Gating Mechanical Allodynia in Mice.


Wang Q, Zhang X, He X, Du S, Jiang Z, Liu P, Qi L, Liang C, Gu N, Lu Y
Anesthesiology. 2020 Feb 19.
PMID: 32101975.


The authors' previous studies have found that spinal protein kinase C γ expressing neurons are involved in the feed-forward inhibitory circuit gating mechanical allodynia in the superficial dorsal horn. The authors hypothesize that nerve injury enhances the excitability of spinal protein kinase C γ expressing interneurons due to disinhibition of the feed-forward inhibitory circuit, and enables Aβ primary inputs to activate spinal protein kinase C γ expressing interneurons.