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Papers: 22 Feb 2020 - 28 Feb 2020
Human Studies, Pharmacology/Drug Development
PAIN TYPE:
Migraine/Headache
2020 Feb 24
J Headache Pain
21
1
Pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) induces headache in healthy volunteers but the precise mechanisms by which PACAP38 leads to headache are unclear. We investigated the headache preventive effect of sumatriptan and ketorolac on PACAP38-induced headache in healthy volunteers. In addition, we explored contribution of vascular mechanisms to PACAP38-induced headache using high resolution magnetic resonance angiography.