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Papers of the Week
Spinal Hevin Mediates Membrane Trafficking of GluA1-containing AMPA Receptors in Remifentanil-induced Postoperative Hyperalgesia in Mice.
Abstract
Hevin, a matricellular protein involved in tissue repair and remodeling, is crucial for initiation and development of excitatory synapses. Besides, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA) is an ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the central nervous system (CNS). This study aimed to investigate the correlation between spinal Hevin and AMPA receptors in remifentanil-induced postoperative hyperalgesia in mice.