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Papers of the Week

Papers: 22 Feb 2020 - 28 Feb 2020

Animal Studies, Pharmacology/Drug Development

2020 Feb 20

Neurosci Lett

Spinal Hevin Mediates Membrane Trafficking of GluA1-containing AMPA Receptors in Remifentanil-induced Postoperative Hyperalgesia in Mice.


Wang Z, Tao Y, Song C, Liu P, Wang C, Li Y, Cui W, Xie K, Zhang L, Wang G
Neurosci Lett. 2020 Feb 20:134855.
PMID: 32088196.


Hevin, a matricellular protein involved in tissue repair and remodeling, is crucial for initiation and development of excitatory synapses. Besides, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA) is an ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the central nervous system (CNS). This study aimed to investigate the correlation between spinal Hevin and AMPA receptors in remifentanil-induced postoperative hyperalgesia in mice.