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Papers of the Week

Papers: 22 Feb 2020 - 28 Feb 2020

Human Studies

2020 Feb 19

Clin J Pain

Contribution of COMT and BDNF Genotype and Expression to the Risk of Transition from Acute to Chronic Low Back Pain.


Baumbauer KM, Ramesh D, Perry M, Bernier Carney K, Julian T, Glidden N, Dorsey SG, Starkweather AR, Young EE
Clin J Pain. 2020 Feb 19.
PMID: 32079998.


A number of factors, including heritability and the environment, contribute to risk of transition from acute low back pain (ALBP) to chronic low back pain (CLBP). The aim of this study was to A) compare somatosensory function and pain ratings at LBP onset between the ALBP and CLBP conditions and (B) evaluate associations between BDNF and COMT polymorphisms and expression levels at LBP onset to acute and chronic pain burden and risk for transition to the chronic pain state.