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Papers of the Week

Papers: 15 Feb 2020 - 21 Feb 2020

Animal Studies, Pharmacology/Drug Development

2020 Feb 14

Neurogastroenterol Motil

Losartan improves visceral sensation and gut barrier in a rat model of irritable bowel syndrome.


Nozu T, Miyagishi S, Nozu R, Takakusaki K, Okumura T
Neurogastroenterol Motil. 2020 Feb 14:e13819.
PMID: 32056324.


Lipopolysaccharide (LPS) or repeated water avoidance stress (WAS) induces visceral allodynia and colonic hyperpermeability via corticotropin-releasing factor (CRF) and proinflammatory cytokines, which is considered to be a rat irritable bowel syndrome (IBS) model. As losartan is known to inhibit proinflammatory cytokine release, we hypothesized that it improves these visceral changes.