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Papers of the Week

2019 Dec 16



Paeonol alleviates primary dysmenorrhea in mice via activating CB2R in the uterus.


Peng Y, Zheng X, Fan Z, Zhou H, Zhu X, Wang G, Liu Z
Phytomedicine. 2019 Dec 16; 68:153151.
PMID: 32058234.


Primary dysmenorrhea is the most common gynaecologic problem in menstruating women and is characterized by spasmodic uterine contraction and pain symptoms associated with inflammatory disturbances. Paeonol is an active phytochemical component that has shown anti-inflammatory and analgesic effects in several animal models. The aim of this study was to explore whether paeonol is effective against dysmenorrhea and to investigate the potential mechanism of cannabinoid receptor signalling.