I am a
Home I AM A Search Login

Papers of the Week


Papers: 8 Feb 2020 - 14 Feb 2020


Pharmacology/Drug Development

PAIN TYPE:
Migraine/Headache


2019


Front Neurol


10

Brain Structural and Functional Imaging Findings in Medication-Overuse Headache.

Abstract

This chapter overviews research neuroimaging findings of patients with medication-overuse headache (MOH). Results indicate; (i) correlations between neuropathology and medication-overuse; (ii) changes in brain morphology and cortical function; and (iii) brain recovery subsequent to withdrawal of medication that was overused. Results of this narrative review indicate exacerbated brain structural and functional changes in regions of the pain-matrix and in regions of the mesocortical-limbic circuit in patients with MOH compared to patients with migraine or compared to healthy controls. Modification of brain morphology as well as an association between brain recovery and medication withdrawal suggest that the MOH disease process involves state (brain modification) and trait-like (brain adaptation and recovery) neuromechanisms.