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Papers of the Week

2020 Feb 10

Crit Care



Cathelicidin preserves intestinal barrier function in polymicrobial sepsis.


Ho J, Chan H, Liang Y, Liu X, Zhang L, Li Q, Zhang Y, Zeng J, Ugwu FN, Ho IHT, Hu W, Yau JCW, Wong SH, Wong W T, Ling L, Cho CH, Gallo RL, Gin T, Tse G, Yu J, et al.
Crit Care. 2020 Feb 10; 24(1):47.
PMID: 32041659.


The intestinal epithelium compartmentalizes the sterile bloodstream and the commensal bacteria in the gut. Accumulating evidence suggests that this barrier is impaired in sepsis, aggravating systemic inflammation. Previous studies reported that cathelicidin is differentially expressed in various tissues in sepsis. However, its role in sepsis-induced intestinal barrier dysfunction has not been investigated.