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Papers of the Week

2020 Feb 10

Br J Clin Pharmacol

Protective effects of doxepin cream on radiation dermatitis in breast cancer: a single arm double-blind randomized clinical trial.


Shariati L, Amouheidari A, Naji Esfahani H, Abed A, Javanmard S H, Laher I, Ghasemi A, Vaseghi G
Br J Clin Pharmacol. 2020 Feb 10.
PMID: 32040868.


Breast cancer is the most frequently occurring cancer in women. Lumpectomy followed by radiotherapy is suggested to be as effective as a total mastectomy. Radiation-induced dermatitis often occurs as a result of breast radiotherapy. Recent studies suggest that doxepin has promising anti-inflammatory properties. This study was undertaken to evaluate the effects of doxepin therapy on radiation dermatitis.