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Papers of the Week

Papers: 8 Feb 2020 - 14 Feb 2020

Animal Studies


2020 Feb 07

J Headache Pain



The distribution of oxytocin and the oxytocin receptor in rat brain: relation to regions active in migraine.


Warfvinge K, Krause D, Edvinsson L
J Headache Pain. 2020 Feb 07; 21(1):10.
PMID: 32028899.


Recent work, both clinical and experimental, suggests that the hypothalamic hormone oxytocin (OT) and its receptor (OTR) may be involved in migraine pathophysiology. In order to better understand possible central actions of OT in migraine/headache pathogenesis, we mapped the distribution of OT and OTR in nerve cells and fibers in rat brain with a focus on areas related to migraine attacks and/or shown previously to contain calcitonin gene related peptide (CGRP), another neuropeptide involved in migraine.