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Papers of the Week

Papers: 8 Feb 2020 - 14 Feb 2020

Human Studies


2020 Feb 06


Noninvasive vagus nerve stimulation and the trigeminal autonomic reflex: An fMRI study.


Möller M, Mehnert J, Schroeder CF, May A
Neurology. 2020 Feb 06.
PMID: 32029547.


The trigeminal autonomic reflex is a physiologic reflex that plays a crucial role in primary headache and particularly in trigeminal autonomic cephalalgias, such as cluster headache. Previous studies have shown that this reflex can be modulated by the vagus nerve, leading to an inhibition of the parasympathetic output of the reflex in healthy participants. The aim of the present study was to characterize neural correlates of the modulatory effect of noninvasive vagus nerve stimulation (nVNS) on the trigeminal autonomic reflex.