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Papers of the Week

2020 Jan-Mar

Indian J Pathol Microbiol



Sinonasal NUT midline carcinoma: A new histological entity.


Vakani PN, Maheshwari J, Maheshwari M, Shah B
Indian J Pathol Microbiol. 2020 Jan-Mar; 63(1):103-105.
PMID: 32031134.


Nuclear protein in testis (NUT) midline carcinoma is poorly differentiated carcinoma defined by rearrangement of NUT gene on 15 to other genes, usually BRD4 on 19. It is first described in 1991. These tumors are most commonly seen in the mediastinum and 35% occur in head and neck. It is a highly aggressive tumor with a median survival of 7 months because of ineffective chemotherapy and undefined treatment. Hence, we must differentiate these tumors from other poorly differentiated tumors. Here, we present a case of NUT midline carcinoma of 44-year male, who presented with headache and dizziness, confirmed by immunohistochemistry of NUT antibody. The aim of this case report is to increase the awareness about this entity in adults with brief review of relevant literature.