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Papers of the Week

Papers: 1 Feb 2020 - 7 Feb 2020

Human Studies

2020 07

Br J Dermatol



Three-dimensional neuroanatomy of the intra-epidermal nervous system.


Tan Y, Ning ZY, Yu X, Kwong TBL, Ng LG, Tey HL
Br J Dermatol. 2020 07; 183(1):174-176.
PMID: 32017051.


Intra-epidermal nerve fibers (IENFs) are presumed to comprise mainly of itch-transmitting nerve fibers, and variations in their density have been studied in itch disorders; epidermal nerve fiber density is also a criterion in diagnosing small fiber neuropathy in clinical neurological practice. IENFs are typically identified with 2-dimensional (2D) histological slides, but 2D sections do not accurately represent nerves, which branch out in three-dimensions (3D).