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Papers of the Week

2020 Mar

Vet Anaesth Analg



Determination of acute tolerance and hyperalgesia to remifentanil constant rate infusion in dogs undergoing sevoflurane anaesthesia.


Ruíz-López P, Navarrete-Calvo R, Morgaz J, Domínguez J M, Quirós-Carmona S, Muñoz-Rascón P, Gómez-Villamandos R J, Fernández-Sarmiento J A, Granados MM
Vet Anaesth Analg. 2020 Mar; 47(2):183-190.
PMID: 32005619.


To determine if acute opioid tolerance (AOT) or opioid-induced hyperalgesia (OIH) could develop and limit the remifentanil-induced reduction in the sevoflurane minimum alveolar concentration (MAC). The response to mechanical nociceptive threshold (MNT) was evaluated and related to OIH.