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Papers of the Week

Papers: 1 Feb 2020 - 7 Feb 2020

Animal Studies

2020 04 01

J Neurosci Methods


Controllable Forces for Reproducible Chronic Constriction Injury Mimicking Compressive Neuropathy in Rat Sciatic Nerve.


Chen S-H, Huang T-C, Wang J-Y, Wu C-C, Hsueh Y-Y
J Neurosci Methods. 2020 04 01; 335:108615.
PMID: 32006536.


Compressive neuropathy is a recurring and challenging disease for patients, regardless of medical or surgical treatment. Neuropathological severity is associated with the force of mechanical compression. Available animal models do not address mechanical issues with reproducible outcomes. We used a chronic constriction injury model to analyze tension-controlled compressive neuropathy and achieve reproducible functional outcomes.