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2020 04

Reg Anesth Pain Med



Does cryoneurolysis result in persistent motor deficits? A controlled study using a rat peroneal nerve injury model.


Shah SB, Bremner S, Esparza M, Dorn S, Orozco E, Haghshenas C, Ilfeld BM, Gabriel RA, Ward S
Reg Anesth Pain Med. 2020 04; 45(4):287-292.
PMID: 32001625.


Cryoneurolysis of peripheral nerves uses localised intense cold to induce a prolonged block over multiple weeks that has the promise of providing potent analgesia outlasting the duration of postoperative pain following surgery, as well as treat other acute and chronic pain states. However, it remains unclear whether persistent functional motor deficits remain following cryoneurolysis of mixed sensorimotor peripheral nerves, greatly limiting clinical application of this modality. To help inform future research, we used a rat peroneal nerve injury model to evaluate if cryoneurolysis results in persistent deficits in motor function.