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Papers of the Week

Papers: 25 Jan 2020 - 31 Jan 2020

Animal Studies

2020 07

Anesth Analg



Differential Regulation of the Glucocorticoid Receptor in a Rat Model of Inflammatory Pain.


Ibrahim SIA, Strong JA, Qualls KA, Ulrich-Lai YM, Zhang J-M
Anesth Analg. 2020 07; 131(1):298-306.
PMID: 31990732.


Anti-inflammatory corticosteroids are a common treatment for different conditions involving chronic pain and inflammation. Clinically used steroids target the glucocorticoid receptor (GR) for its anti-inflammatory effects. We previously reported that GR in sensory neurons may play central roles in some pain models and that GR immunoreactivity signal in dorsal root ganglia (DRG) decreased after local inflammation of the DRG (a model of low back pain). In the current study, we aimed to determine if similar changes in GR signal also exist in a skin inflammation model, the complete Freund's adjuvant (CFA) model (a model of peripheral inflammatory pain), in which the terminals of the sensory neurons rather than the somata are inflamed.