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Papers of the Week

2020 Feb

J Dermatol Sci



Topical transient receptor potential ankyrin 1 antagonist treatment attenuates nociception and inflammation in an ultraviolet B radiation-induced burn model in mice.


Fialho M F P, da Brum E S, Pegoraro N S, Couto A C G, Trevisan G, Cruz L, Oliveira S M
J Dermatol Sci. 2020 Feb; 97(2):135-142.
PMID: 31982303.


Ultraviolet B (UVB) radiation exposure promotes sunburn and thereby acute and chronic inflammatory processes, contributing to pain development and maintenance. New therapeutic alternatives are necessary because typical treatments can cause adverse effects. An attractive alternative would be to target the transient receptor potential ankyrin 1 (TRPA1), a calcium-permeable, non-selective cation channel, which is involved in a variety of inflammatory pain models.