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Papers of the Week

Papers: 25 Jan 2020 - 31 Jan 2020

Animal Studies, Pharmacology/Drug Development

2020 Mar 15

Life Sci


Design and synthesis of N‑(benzylpiperidinyl)‑4‑fluorobenzamide: A haloperidol analog that reduces neuropathic nociception via σ receptor antagonism.


Déciga-Campos M, Melo-Hernández L A, Torres-Gómez H, Wünsch B, Schepmann D, González-Trujano M E, Espinosa-Juárez J, López-Muñoz F J, Navarrete-Vázquez G
Life Sci. 2020 Mar 15; 245:117348.
PMID: 31981633.


Haloperidol is a neuroleptic drug with high affinity towards the σ receptor (σR), acting as antagonist that decreases neuropathic pain, but has CNS side effects. This work describes the design and synthesis of a novel analog N‑(1‑benzylpiperidin‑4-yl)‑4‑fluorobenzamide (LMH-2), which produced antihyperalgesic and antiallodynic effects in rats with neuropathy induced by chronic constriction injury of the sciatic nerve (CCI), being more active than gabapentin (The most widely used drug for the treatment of neuropathic pain).