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Papers of the Week

Papers: 25 Jan 2020 - 31 Jan 2020

Animal Studies, Pharmacology/Drug Development

2020 05

Neurogastroenterol Motil



Pharmacological evaluation of a novel corticotrophin-releasing factor 1 receptor antagonist T-3047928 in stress-induced animal models in a comparison with alosetron.


Itomi Y, Tanaka T, Matsushita K, Kawamura T, Kojima T, Aso K, Matsumoto-Okano S, Tsukimi Y
Neurogastroenterol Motil. 2020 05; 32(5):e13795.
PMID: 31970891.


The major symptoms of irritable bowel syndrome (IBS) are changes in bowel habits and abdominal pain. Psychological stress is the major pathophysiological components of IBS. Corticotropin-releasing factor (CRF) is a well-known integrator in response to psychological stress. In this study, a novel CRF1 receptor antagonist T-3047928 was evaluated in stress-induced IBS models of rats to explore its potency for IBS.