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2020 03

Biol Psychiatry Cogn Neurosci Neuroimaging



Neuroanatomical Risk Factors for Posttraumatic Stress Disorder in Recent Trauma Survivors.


Ben-Zion Z, Artzi M, Niry D, Keynan N J, Zeevi Y, Admon R, Sharon H, Halpern P, Liberzon I, Shalev AY, Hendler T
Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 03; 5(3):311-319.
PMID: 31973980.


Low hippocampal volume could serve as an early risk factor for posttraumatic stress disorder (PTSD) in interaction with other brain anomalies of developmental origin. One such anomaly may well be the presence of a large cavum septum pellucidum (CSP), which has been loosely associated with PTSD. We performed a longitudinal prospective study of recent trauma survivors. We hypothesized that at 1 month after trauma exposure the relation between hippocampal volume and PTSD symptom severity will be moderated by CSP volume, and that this early interaction will account for persistent PTSD symptoms at subsequent time points.