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2020 04




Dexamethasone Dose and Early Postoperative Recovery after Mastectomy: A Double-blind, Randomized Trial.


Steinthorsdottir K J, Awada H N, Abildstrøm H, Kroman N, Kehlet H, Aasvang E K
Anesthesiology. 2020 04; 132(4):678-691.
PMID: 31977520.


Dexamethasone is an effective antiemetic and may facilitate initial postoperative recovery after mastectomyWhether 24 mg is more effective than 8 mg remains unknown WHAT THIS ARTICLE TELLS US THAT IS NEW: Dexamethasone (24 mg) did not increase the number of patients eligible to skip the postanesthetic care unitPain scores were low and nausea rare in both groupsDexamethasone (24 mg) was not preferable to 8 mg BACKGROUND:: Pain and nausea are the most common challenges in postoperative recovery after mastectomy. Preventive measures include multimodal analgesia with preoperative glucocorticoid. The aim of this study was to investigate whether 24 mg of preoperative dexamethasone was superior to 8 mg on early recovery after mastectomy in addition to a simple analgesic protocol.