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Papers of the Week

Papers: 18 Jan 2020 - 24 Jan 2020

Animal Studies, Pharmacology/Drug Development

2020 05

Br J Pharmacol



Opioid presynaptic disinhibition of the midbrain periaqueductal grey descending analgesic pathway.


Lau BK, Winters BL, Vaughan CW
Br J Pharmacol. 2020 05; 177(10):2320-2332.
PMID: 31971607.


The midbrain periaqueductal grey (PAG) plays a central role in modulating pain through a descending pathway that projects indirectly to the spinal cord via the rostroventral medial medulla (RVM). While opioids are potent analgesics that target the PAG, their cellular actions on descending projection neurons are unclear.