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Papers of the Week

Papers: 18 Jan 2020 - 24 Jan 2020

Pharmacology/Drug Development

2021 02 01

Cold Spring Harb Perspect Med



Opioid-Induced Molecular and Cellular Plasticity of Ventral Tegmental Area Dopamine Neurons.


Doyle MA, Mazei-Robison MS
Cold Spring Harb Perspect Med. 2021 02 01; 11(2).
PMID: 31964652.


Opioid drugs are highly valued as potent analgesics; however, there are significant risks associated with long-term use because of their abuse liability. Opioids cause changes in ventral tegmental area (VTA) gene expression and cell activity that have been linked to addiction-related behaviors in rodent models. Here, we focus on VTA dopamine (DA) neurons and review the cellular, structural, and synaptic plasticity changes induced by acute and chronic opioid exposure. We also discuss many avenues for future research including determination of whether opioid neuroadaptations are specific for subpopulations of VTA DA neurons. A better understanding of the molecular adaptations within the cells and circuits that drive opioid abuse is crucial for the development of better treatments for substance use disorders and to create novel, safer pain-relieving therapeutics.