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Papers of the Week

Papers: 18 Jan 2020 - 24 Jan 2020

Animal Studies, Human Studies

2020 01 17

J Transl Med



The capsaicin receptor TRPV1 is the first line defense protecting from acute non damaging heat: a translational approach.


Rosenberger DC, Binzen U, Treede R-D, Greffrath W
J Transl Med. 2020 01 17; 18(1):28.
PMID: 31952468.


Pain is the vital sense preventing tissue damage by harmful noxious stimuli. The capsaicin receptor TRPV1 is activated by noxious temperatures, however, acute heat pain is only marginally affected in mice after TRPV1 knockout but completely eliminated in mice lacking TRPV1 positive fibers. Exploring contribution of candidate signal transduction mechanisms to heat pain in humans needs translational models.