Browse by Audience
Skip to content
Papers of the Week
The capsaicin receptor TRPV1 is the first line defense protecting from acute non damaging heat: a translational approach.
Abstract
Pain is the vital sense preventing tissue damage by harmful noxious stimuli. The capsaicin receptor TRPV1 is activated by noxious temperatures, however, acute heat pain is only marginally affected in mice after TRPV1 knockout but completely eliminated in mice lacking TRPV1 positive fibers. Exploring contribution of candidate signal transduction mechanisms to heat pain in humans needs translational models.