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Papers of the Week

2020 May

Am J Emerg Med



Intrathecal bupivacaine and morphine toxicity leading to transient hypotension and delayed status epilepticus.


Sidlak AM, Yanta JH, Lynch MJ
Am J Emerg Med. 2020 May; 38(5):1046.e5-1046.e7.
PMID: 31952869.


Local anesthetic systemic toxicity characteristically occurs after inadvertent intravascular injection of local anesthetics; however, it is unclear if similar symptoms arise after intrathecal adminstration. Intrathecal use of local anesthetics for chronic pain is increasing and carries a potential risk of toxicity. Experience with the presenting symptoms and appropriate treatment for intrathecal local anesthetic toxicity is limited.