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Papers of the Week

2020 Mar 15

J Neuroimmunol


Lavandula angustifolia essential oil inhalation reduces mechanical hyperalgesia in a model of inflammatory and neuropathic pain: The involvement of opioid and cannabinoid receptors.


Donatello N N, Emer A A, Salm D C, Ludtke D D, Bordignon S A S R, Ferreira J K, Salgado A S I, Venzke D, Bretanha LC, Micke GA, Martins DF
J Neuroimmunol. 2020 Mar 15; 340:577145.
PMID: 31945593.


Lavandula angustifolia (LaEO) essential oil has been widely used by aromatherapy in the treatment of various clinical conditions, with evidence of its analgesic and anti-inflammatory potential. Our results demonstrate that sixty-five substances were identified in LaEO. Among the compounds found, the major ones were linalool (30.61%) and linalyl acetate (20.36%). We found that LaEO inhalation reduces mechanical hyperalgesia in conditions of chronic inflammatory and neuropathic pain. Furthermore, this effect seems to be mediated by peripheral and central opioid and cannabinoid 2 receptors. The findings of the present study suggests that the LaEO inhalation is effective on the chronic pain treatment.