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Papers of the Week

2020 Feb 07

J Neural Eng



Granger causality analysis of rat cortical functional connectivity in pain.


Guo X, Zhang Q, Singh A, Wang J, Chen Z S
J Neural Eng. 2020 Feb 07; 17(1):016050.
PMID: 31945754.


The primary somatosensory cortex (S1) and the anterior cingulate cortex (ACC) are two most important brain regions encoding the sensory-discriminative and affective-emotional aspects of pain, respectively. However, the functional connectivity of these two areas during cortical pain processing remains unclear. Developing methods to dissect the functional connectivity and directed information flow between cortical pain circuits can reveal insight into neural mechanisms of pain perception.