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Papers of the Week

2020 Feb

J Clin Neurosci


Prevention of peridural adhesions in spinal surgery: Assessing safety and efficacy of Chitogel with Deferiprone in a sheep model.


Vediappan R S, Mascarenhas A, Nguyen-Hoang A, Anne Fong S, Jukes A, Richter K, Bassiouni A, Patel S, Chryssidis S, Otto S, Moratti S, James Psaltis A, Vreugde S, Wormald P-J
J Clin Neurosci. 2020 Feb; 72:378-385.
PMID: 31948884.


Spinal laminectomy is a common procedure performed to relieve neural compression in patients suffering from myelopathy or radiculopathy. However, up to 40% of patients suffer from persistent post-operative pain and disability, a condition known as Failed Back Surgery Syndrome (FBSS). Excessive scarring in the surgical bed is implicated as a cause. Hydrogels have been proposed to prevent adhesion formation post-laminectomy; however, their efficacy has not been proven. This study uses Chitogel complexed with the iron chelator Deferiprone (Def) to prevent adhesion formation in a sheep laminectomy model.