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Papers: 11 Jan 2020 - 17 Jan 2020

Human Studies


2020 Jan 08

Medicines (Basel)



Association between Prurigo Nodularis and Etiologies of Peripheral Neuropathy: Suggesting a Role for Neural Dysregulation in Pathogenesis.


Hughes J-D M, Woo TE, Belzberg M, Khanna R, Williams KA, Kwatra MM, Hassan S, Kwatra SG
Medicines (Basel). 2020 Jan 08; 7(1).
PMID: 31936197.


: Prurigo nodularis (PN) is an intensely pruritic skin condition of considerable morbidity. However, the pathogenesis of PN and its association with underlying neuropathy is unclear. : We sought to investigate the association between PN and etiologies of peripheral neuropathy. : A cross-sectional analysis of adult patients (≥18-year-old) with PN, AD, and Psoriasis at the Johns Hopkins Health System over a six-year period (January 2013-January 2019) was performed. The strength of association with etiologies of peripheral neuropathy were compared to a control cohort of individuals without PN, as well as those with AD or psoriasis. : A total of 1122 patients with PN were compared to 10,390 AD patients, 15,056 patients with psoriasis, and a control cohort of 4,949,017 individuals without PN, with respect to 25 comorbidities associated with peripheral neuropathies. : Comparisons between peripheral neuropathies and PN represent associations but are not causal relationships. : Prurigo nodularis is strongly associated with peripheral neuropathies, suggesting a role for neural dysregulation in pathogenesis.