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Papers of the Week

Papers: 11 Jan 2020 - 17 Jan 2020

Animal Studies


2020 Jan 14

J Headache Pain



Microglia P2X4R-BDNF signalling contributes to central sensitization in a recurrent nitroglycerin-induced chronic migraine model.


Long T, He W, Pan Q, Zhang S, Zhang D, Qin G, Chen L, Zhou J
J Headache Pain. 2020 Jan 14; 21(1):4.
PMID: 31937253.


According to our previous study, microglia P2X4 receptors (P2X4Rs) play a pivotal role in the central sensitization of chronic migraine (CM). However, the molecular mechanism that underlies the crosstalk between microglia P2X4Rs and neurons of the trigeminal nucleus caudalis (TNC) is not fully understood. Therefore, the aim of this study is to examine the exact P2X4Rs signalling pathway in the development of central sensitization in a CM animal model.