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Papers of the Week

Papers: 11 Jan 2020 - 17 Jan 2020

Human Studies

2020 07




Familial trigeminal neuralgia – a systematic clinical study with a genomic screen of the neuronal electrogenisome.


Di Stefano G, Yuan J-H, Cruccu G, Waxman SG, Dib-Hajj SD, Truini A
Cephalalgia. 2020 07; 40(8):767-777.
PMID: 31928344.


This cross-sectional study examined, for the first time, a large cohort of patients with trigeminal neuralgia, to ascertain the occurrence of familial cases, providing a systematic description of clinical features of familial disease. Since there is evidence linking hyperexcitability of trigeminal ganglion neurons to trigeminal neuralgia, we also carried out an exploratory genetic analysis of the neuronal electrogenisome in these patients.