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Papers of the Week

2020 Jan

Mol Metab


Lack of resolution sensor drives age-related cardiometabolic and cardiorenal defects and impedes inflammation-resolution in heart failure.


Tourki B, Kain V, Pullen AB, Norris PC, Patel N, Arora P, Leroy X, Serhan CN, Halade GV
Mol Metab. 2020 Jan; 31:138-149.
PMID: 31918915.


Recently, we observed that the specialized proresolving mediator (SPM) entity resolvin D1 activates lipoxin A/formyl peptide receptor 2 (ALX/FPR2), which facilitates cardiac healing and persistent inflammation is a hallmark of impaired cardiac repair in aging. Splenic leukocyte-directed SPMs are essential for the safe clearance of inflammation and cardiac repair after injury; however, the target of SPMs remains undefined in cardiac healing and repair.