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Papers of the Week

2020 May 01

Am J Respir Crit Care Med



Pitolisant for Daytime Sleepiness in Obstructive Sleep Apnea Patients Refusing CPAP: A Randomized Trial.


Dauvilliers Y, Verbraecken J, Partinen M, Hedner J, Saaresranta T, Georgiev O, Tiholov R, Lecomte I, Tamisier R, Lévy P, Scart-Gres C, Lecomte J-M, Schwartz J-C, Pépin J-L
Am J Respir Crit Care Med. 2020 May 01; 201(9):1135-1145.
PMID: 31917607.


Excessive daytime sleepiness is a common disabling symptom in obstructive sleep apnea syndrome. We aimed to evaluate the efficacy and safety of pitolisant, a selective histamine H3-receptor antagonist with wake-promoting effects, for treatment of daytime sleepiness in patients with moderate to severe obstructive sleep apnea refusing continuous positive airway pressure treatment.