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Papers of the Week

2020 Mar

Biomed Pharmacother


New 2-amino-pyridinyl-N-acylhydrazones: Synthesis and identification of their mechanism of anti-inflammatory action.


de Cordeiro N M, Freitas RHCN, Fraga C A M, Fernandes P D
Biomed Pharmacother. 2020 Mar; 123:109739.
PMID: 31918210.


The main aim of this paper was the synthesis and the evaluation of the anti-inflammatory activity of LASSBio-1828 (an amino-pyridinyl-N-acylhydrazone) and its respective hydrochloride, based on a p38α MAPK inhibitor (LASSBio-1824) previously synthesized by our group.