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Papers of the Week

Papers: 4 Jan 2020 - 10 Jan 2020

Animal Studies

2020 Jan 09

J Biomed Sci



Neuropeptide S-initiated sequential cascade mediated by OX, NK, mGlu and CB receptors: a pivotal role in stress-induced analgesia.


Lee M T, Chiu Y-T, Chiu Y-C, Hor C C, Lee H-J, Guerrini R, Calo G, Chiou L-C
J Biomed Sci. 2020 Jan 09; 27(1):7.
PMID: 31915019.


Stress-induced analgesia (SIA) is an evolutionarily conserved phenomenon during stress. Neuropeptide S (NPS), orexins, substance P, glutamate and endocannabinoids are known to be involved in stress and/or SIA, however their causal links remain unclear. Here, we reveal an unprecedented sequential cascade involving these mediators in the lateral hypothalamus (LH) and ventrolateral periaqueductal gray (vlPAG) using a restraint stress-induced SIA model.