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Papers of the Week

Papers: 4 Jan 2020 - 10 Jan 2020

Animal Studies, Pharmacology/Drug Development

2020 Apr

Psychopharmacology (Berl)



Behavioral pharmacology of the mixed-action delta-selective opioid receptor agonist BBI-11008: studies on acute, inflammatory and neuropathic pain, respiration, and drug self-administration.


Stevenson GW, Giuvelis D, Cormier J, Cone K, Atherton P, Krivitsky R, Warner E, St Laurent B, Dutra J, Bidlack JM, Szabò L, Polt R, Bilsky EJ
Psychopharmacology (Berl). 2020 Apr; 237(4):1195-1208.
PMID: 31912192.


The present study characterized the behavioral pharmacology of a novel, mixed-action delta-selective (78:1) opioid receptor agonist, BBI-11008. This glycopeptide drug candidate was tested in assays assessing antinociception (acute, inflammatory, and neuropathic pain-like conditions) and side-effect endpoints (respiratory depression and drug self-administration).