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Papers of the Week


Papers: 4 Jan 2020 - 10 Jan 2020

PAIN TYPE:
Migraine/Headache


2020 01


Headache


60


1

Remote Electrical Neuromodulation (REN) for the Acute Treatment of Migraine.

Authors

Rapoport AM, Lin T, Tepper SJ
Headache. 2020 01; 60(1):229-234.
PMID: 31913517.

Abstract

There is a significant unmet need for novel, effective, and well-tolerated acute migraine treatments. Remote electrical neuromodulation (REN) is a non-pharmacological, non-invasive, acute migraine treatment that stimulates upper arm peripheral nerves to induce conditioned pain modulation – an endogenous analgesic mechanism in which a conditioning stimulation inhibits pain in remote body regions. This review presents the method of action and the clinical data of REN and discusses its potential patient benefits. The clinically meaningful efficacy, together with a very favorable safety profile, suggests that REN may offer a promising alternative for the acute treatment of migraine and could be considered first-line treatment in some patients.